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Oct 18,2017
AmCaid Melatonin
Melatonin is a naturally occurring neurotransmitter secreted by the pineal gland in the brain at the onset of darkness, initiating the sleep cycle. Synthetic melatonin has been used as a remedy for jet lag, and also works well for adults as a treatment for occasional insomnia.[1]

Supplement Facts
Serving Size 1 to 2 Liquid Vcaps
Made in USA
UPS Graded Melatonin 2.5 mg
* % Daily Value Not Established

Because of its use in promoting sleep, melatonin is increasingly used in the treatment of sleep disturbance in adult and children. The National Sleep Foundation [2] suggests that the product may be useful for teenagers who experience delayed-sleep-phase syndrome, which is an inability to fall asleep during the early nighttime hours that causes problems in awakening the next morning. One study of 20 children with developmental disabilities found that children given melatonin fell asleep significantly more quickly, but did not experience overall longer sleep durations or wake less frequently. [3] A second slightly larger study of 46 children with neurological development disorders found that sleep improved in 34 of the children and none experienced side effects. [4] Other research data indicates that melatonin is effective in helping developmentally delayed children, including autistic children, with sleep problems [5].Only a very few studies have examined the use of this hormone in children without disability. For example, a study of 40 elementary school children without neurological problems who were experiencing delayed sleep onset found that over the duration of the 4-week study, melatonin was relatively safe and significantly more effective than placebo in advancing sleep onset and increasing sleep.

What is the Pediatric dosage? In one research, 49 mothers agreed to give their children melatonin and keep diaries and records of the differences it made to their children's sleep patterns. The children were given 2.5mg of melatonin per night if they were under five years of age and 5mg if they were over five. The dose was increased, if necessary, to a maximum of 7.5mg in children under two years and 10mg over this age. The children with sleep problems also had either cerebral palsy, learning difficulties, epilepsy, autistic spectrum disorders or Down syndrome. Only seven children were also visually impaired. They found that the melatonin significantly improved almost all aspects of sleep in most of the children and around 93% recorded significant benefits. The average number of hours sleep that the children had each week increased by around 10%, from 54 hours/week before taking the melatonin to 66 hours/week while taking the melatonin. The number of interruptions to sleep each week decreased by 50% from an average of seven interruptions per week before taking the melatonin, to 3.5 interruptions while taking the drug. Also, the number of hours of interrupted sleep decreased by 45%, from nine hours awake each week during a sleep interruption pre melatonin, to five hours per week while taking melatonin. There were no major side effects from the medication in any of the children and importantly there was no change in the frequency or severity of seizures in children with epilepsy. Boys and girls were equally likely to respond well to melatonin. The visually impaired children were the most likely to have success with melatonin, but around three-quarters of the fully sighted children also responded very well. [6]

**All AmCaid Products are 100% USP grade material and are free of fillers and preservatives**

Reference:
  1. Cochrane Review Abstracts. Melatonin for the prevention and treatment of jet lag. April 1, 2002.
  2. Goldberg JR. Melatonin: The Facts. National Sleep Foundation. Available at: http://www.sleepfoundation.org/publications/melatoninthefact.html#2 Accessed January 22, 2003.
  3. Dodge NN, Wilson GA. Melatonin for treatment of sleep disorders in children with developmental disabilities. J Child Neurol. 2001;16:581-584.
  4. Ross C, Davies P, Whitehouse W. Melatonin treatment for sleep disorders in children with neurodevelopmental disorders: an observational study. Dev Med Child Neurol. 2002;4:339-344.
  5. Melatonin Treatment for Insomnia in Pediatric Patients with Attention-Deficit/Hyperactivity Disorder, Ann Pharmacother. 2009 Dec 22.
  6. Ross & Whitehouse. Melatonin treatment for sleep disorders in children with neurodevelopmental disorders: an observational study. Developmental Medicine & Child Neurology May 2002; 44: 339-44.


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